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Pharmaceutical intermediates

Anti-tumor drugs
Name	Key intermediate	CAS NO
Axitinib	3,6-diiodo(1H)indazole Methyl 2-mercaptobenzoate	319472-78-1 4892-02-8
Crizotinib	4-Iodo-1H-pyrazole (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester (R)-5-bromo-3-(1-	3469-69-0 877397-70-1 877399-50-3 877399-00-3
Lapatinib	2-(Methylsulfonyl)-ethanamine hydrochloride N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine 3-Chloro-4-(3-fluorobenzyloxy)aniline	104458-24-4 231278-20-9 202197-26-0
Pazopanib	3-Methyl-6-nitro-1H-Indazole 2,3-dimethyl-6-nitro-2H-indazole 2,3-dimethyl-2H-indazol-6-amine 2,4-Dichloropyrimidine 3-Amino-6-methylbenzenesulfonam	6494-19-5 444731-73-1 444731-72-0 3934-20-1 6973-09-7
Regorafenib	3-Fluoro-4-Nitrophenol 3-Fluoro-4-aminophenol	394-41-2 399-95-1
Afatinib	trans 4-Dimethylaminocrotonic acid hydrochloride	848133-35-7
Gefitinib	4-(3-chloropropyl)-morpholin	7357-67-7

Anti-inflammatory drugs
Name	Key intermediate	CAS NO
Tofacitinib	1-benzyl-4-methylpiperidin-3-ol 4-methylbenzenesulfonate (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine hydrochloride 2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine 3-bis(4-	493040-20-3 477600-70-7 90213-66-4 477600-71-8
Formoterol	2-Bromo-4'-Benzyloxy-3'-nitroacetophenone (1R,2S)-1-Amino-2-indanol	43229-01-2 136030-00-7
Umeclidiniu	Phenyl(piperidin-4-yl)methanone	37586-22-4

Hypoglycemic agents
Name	Key intermediate	CAS NO
Alogliptin	(R)-3-Boc-aminopiperidine	309956-78-3
Anagliptin	2-Methylpyrazolo[1,5-a]pyriMidine-6-carboxylic acid 2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxamide 1,2-Diamino-2-methylpropane	739364-95-5 338953-49-4 811-93-8
Dapagliflozin	5-Bromo-2-chloro-4’-ethoxydiphenylmethane 4-Iodo-1-chloro-2-(4-ethoxybenzyl)benzene (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone	461432-23-5 1103738-29-9 461432-22-4
Vildagliptin	3-Amino-1-adamantanol (2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile L-Prolinamide	702-82-9 207557-35-5 7531-52-4
Canagliflozin	2-(4-fluorophenyl)thiophene (5-(4-fluorophenyl)thiophen-2-yl)(5-iodo-2-methylphenyl)methanone 2-(4-fluorophenyl)-5-(5-iodo-2-methylbenzyl)thiophene (5-bromo-2-methylph	58861-48-6 1071929-08-2 898566-17-1 1132832-75-7 1030825-20-7

Anticoagulants drugs
Name	Key intermediate	CAS NO
Dabigatran	N-(4-Cyanophenyl)glycine 4-(Methylamino)-3-nitrobenzoic Acid 3-(Pyridin-2-ylamino)propanoate Ethyl N-[3-amino-4-(methylamino)benzoyl]-N-pyridin-2-yl-beta-alaninate	42288-26-6 41263-74-5 103041-38-9 212322-56-0
Ticagrelor	4,6-dichloro-5-nitro-2-(propylsulfanyl)pyrimidine (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (1R,2R)-2-(3,4-difluorophenyl) cyclopropanamine(S)-(carboxylato(phenyl) methyl)h	145783-14-8 220352-38-5 376608-71-8

Antiepileptics drugs

Name

Key intermediate

CAS NO

Retigabine (ezogabine)

2-Amino-5-[(4-fluorobenzyl)amino]-1-nitrobenzene

4-(4-Fluorobenzylamino)-1,2-phenylenediamine

150812-21-8

491871-67-1

Anti-HIV drugs
Name	Key intermediate	CAS NO
Abacavir	(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide (1S,4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-Cyclopentene-1- methano	171887-03-9 136522-33-3
Etravirine	(4-Cyanophenyl)guanidine 4-Aminobenzonitrile	5637-42-3 873-74-5
Ritonavir	154212-59-6 154212-61-0 144164-11-4	154212-59-6 154212-61-0 144164-11-4
Atazanavir	4-(2-Pyridinyl)- benzaldehyde N-(Methoxycarbonyl)-L-tert-leucine Tert-Butyl[(1S)-1-(2R)-Oxiranyl-2-Phenylethyl]carbamate 2-[[4-(2-Pyridinyl)phenyl]methylene]- hydrazin	127406-56-8 162537-11-3 98760-08-8 198904-84-6 198904-86-8
Aliskiren	5-Bromo 2-methoxy phenol	37942-01-1

Antihypertensives drugs
Name	Key intermediate	CAS NO
Aliskiren	5-Bromo 2-methoxy phenol	37942-01-1

Custom Products

Code	Name	CAS NO
112	Chloro [1,1-biphenyl] 2,5-diol	117-71-5
113	3-amino-2-methoxy-dibenzofuran	5834-17-3
120	2-methoxy - dibenzofuran	20357-70-4
394	2- hydroxydibenzofuran	86-77-1
396	3-nitro-2-methoxy-dibenzofuran	2672-81-3
392	3-hydroxy -N- (2- methoxy-3-dibenzofuran-yl) -2-naphthalene-carboxamide	96460-88-7
810	3-phenoxy-propionic acid ethyl ester	22409-91-2
368	Heptachloropropane	3849-33-0
246	Dibenzyl diphosphite of tetraethyl	4546-4-7
372	2-nitropropane	79-46-9
373	2,3-dimethyl-2,3-dinitro-butane	3964-18-9
202	4,4-diiodo-biphenyl	3001-15-8
1016	2,4 Nitrodiphenylamine	961-68-2
1024	Cinnamic acid isopropyl ester	3001-15-8
325	Dichloro glyoxime	2038-44-0
1037	Acetoacetate (2-methoxy) ethyl	22502-03-0
1074	D-3-bromo-camphor-8-sulfonic acid ammonium salt	22502-03-0
111	Arecoline hydrobromide hydrochloride	300-08-3
201	4- iodobiphenyl	1591-31-7
375	2-methyl-4,6-dichloro-5-aminopyrimidine	39906-04-2
601	Diethyl oxaloacetate sodium salt	40876-98-0
990	O Nitrodiphenylamine	119-75-5
925	Azomethine -H- monosodium salt monohydrate	206752-32-1
1035	4-hydroxyisophthalic acid	636-46-4
	6-Chloro-indol-2-one	56341-37-8
	2- -aminoindan	2975-41-9
	1- Bromocarbazole	16807-11-7
	N- methyl trifluoroacetamide	815-06-5
	2,8-dibromo dibenzofuran	10016-52-1
	2-bromo-1- (2,2-dimethyl -4H-1,3- benzodioxin-6-yl) ethanone	102293-80-1
	N, N- diethyl ethyl acrylate	13894-28-5
	3'-nitro-4'-benzyloxy-2-bromoacetophenone	43229-01-2
600	6-hydroxy-1-naphthoic acid	2437-17-4
	Between 4-methoxy-phthalate	2206-43-1
	2-nitropropane	79-46-9
	D-3-bromo-camphor-8-sulfonic acid ammonium salt	D-3-bromo-camphor-8-sulfonic acid ammonium salt
	dioctyl 3,4,5,6-tetrabromophthalate	26040-751-7
	Benzonitrile, 3-ethoxy-4-methoxy-	60758-86-3
	1-Bromo-3-ethoxy-4-methoxybenzene	52849-52-2
	4-Bromoveratrole	2859-78-1
	Cyclen	294-90-6
	Amisulpride	71675-85-9
	Valproic acid	99-66-1
	Cyclobutanecarboxylic acid	3721-95-7
	DL-Mandelic acid	90-64-2;611-72-3

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